Renal artery stenosis (RAS) is an important cause of chronic renal dysfunction. Wang, Diping Warner, Gina M Yin, Ping Knudsen, Bruce E Cheng, Jingfei Butters, Kim A Lien, Karen R Gray, Catherine E Garovic, Vesna D Lerman, Lilach O Textor, Stephen C Nath, Karl A Simari, Robert D Grande, Joseph P Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders.
Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. controls after 6 weeks of CRF but was impaired after 10 weeks of CRF. In contrast, CRF mice showed lower levels of anxiety in some tests. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In the present study, we examined the impact of CRF on behavior (anxiety, recognition and ischemic stroke severity in a well-defined murine model of CRF. However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. Neurological Disorders in a Murine Model of Chronic Renal Failureĭirectory of Open Access Journals (Sweden)įull Text Available Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF.
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